Circular RNA hsa_circ_0044234 as distinct molecular signature of triple negative breast cancer: a potential regulator of GATA3

Table 2 The Association between relative expression of circ_0044234 in breast cancer and clinicopathological features of the patients

Characteristic	Subgroups	No. of patients (%)	Median (expression of circ….)	P-value
Age	< 50	54 (56.8%)	1.58	0.717
Age	≥ 50	41 (43.2%)	1.73	0.717
Tumor size	< 2	18 (19%)	1.88	0.845
	2–5	72 (75.8%)	1.59
	> 5	5 (5.2%)	1.49
Estrogen receptor	Positive	38 (40%)	2.54	0.0002
Estrogen receptor	Negative	57 (60%)	1.04	0.0002
progesterone receptor	Positive	37 (38.9%)	2.60	0.0001
progesterone receptor	Negative	58 (61.1%)	1.03	0.0001
HER2	Positive	35 (36.8%)	2.03	0.142
HER2	Negative	60 (63.2%)	1.41	0.142
Ki67^a	High	47 (57.3)	0.62	< 0.0001
Ki67^a	Low	35 (42.7)	1.74	< 0.0001
Histologic grade^b	G1	20 (21.5)	2.52	0.001
	G2	47 (50.5)	1.92
	G3	26 (28)	0.48
Lymph nodes metastasis^c	Yes	36 (40)	1.07	0.030
Lymph nodes metastasis^c	No	54 (60)	2.01	0.030
Histologic type of invasive carcinoma	IDC	68 (94.5%)	0.83	0.140
Histologic type of invasive carcinoma	ILC	4 (5.5%)	3.22	0.140

IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, Bold values denote statistical significance at the p < 0.05 level
^aData on thirteen patients are lacking. A cut-off point of 25% of positive cells per field was used to distinguish between the categories of high (> 25%) and low (≤ 25%) Ki67 expression
^bData on five patients are lacking
^cData on two patients are lacking

ISSN: 1475-2867