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Fig. 4 | Cancer Cell International

Fig. 4

From: Circ_0001721 enhances doxorubicin resistance and promotes tumorigenesis in osteosarcoma through miR-758/TCF4 axis

Fig. 4

Inhibition of miR-758 abrogated the effect of circ_0001721 knockdown on DXR resistance in DXR-resistant OS cells. KHOS/DXR and MG63/DXR cells were introduced with si-NC, si-circ#2, si-circ#2 + in-miR-NC or si-circ#2 + in-miR-758, respectively. A The level of miR-758 was examined by qRT-PCR. B, C IC50 of DXR was determined by CCK-8 assay. D, E Cell viability was assessed using CCK-8 assay. F, G Cell migration and invasion were evaluated by transwell assay. H The apoptosis rate of KHOS/DXR and MG63/DXR cells was tested by flow cytometry. I, J The levels of multidrug resistance-related markers and Wnt/β-catenin pathway-associated proteins were examined by western blot. *P < 0.05

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