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Fig. 6 | Cancer Cell International

Fig. 6

From: LINC00115 promotes stemness and inhibits apoptosis of ovarian cancer stem cells by upregulating SOX9 and inhibiting the Wnt/β-catenin pathway through competitively binding to microRNA-30a

Fig. 6

LINC00115 participates in the maintenance and apoptosis of OCSCs through the miR-30a/SOX9 axis. A Microscopic observation of spheres (100 ×) and sphere-forming rate of OCSCs measured by sphere-forming assay; B, C Relative levels of CD133, SOX9, CD44, NANOG, and POU5F1 were detected by RT-qPCR and Western blot analysis; D Cell apoptosis was measured by flow cytometry; E Relative Caspase-3 activity; F Relative percentage of DNA damage in cell supernatant of each group. VS the sh1 + inhibitor-NC group, * p < 0.05; vs the sh1 + vector-NC group, # p < 0.05. Data were analyzed using one-way ANOVA and Tukey’s multiple comparison test. The experiment was performed in triplicate and data were expressed as means ± standard deviation

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Cancer Cell International

ISSN: 1475-2867

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