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Fig. 4 | Cancer Cell International

Fig. 4

From: Myc-associated zinc-finger protein promotes clear cell renal cell carcinoma progression through transcriptional activation of the MAP2K2-dependent ERK pathway

Fig. 4

MAP2K2 is upregulated in ccRCC and is positively correlated with MAZ. A The MAP2K2 mRNA level was detected by qRT-PCR in tumor (T, n  =  45) and normal kidney (N, n  =  45) tissues. B The expression of MAP2K2 mRNA was analyzed in the TCGA database (http://ualcan.path.uab.edu/analysis.html). C Kaplan–Meier analysis was used to analyze the overall survival of ccRCC patients from the TCGA database with low (n  =  130) and high (n  =  130) MAP2K2 levels (http://www.oncolnc.org/). D, E The correlation between MAZ and MAP2K2 mRNA expression in PCa tissues was analyzed by Pearson correlation analysis of our clinical data (R  =  0.6443, P  <  0.0001). D or other data published in the TCGA database E (http://ualcan.path.uab.edu/analysis.html). All data are expressed as the mean  ±  SEM from three independent experiments. *P  <  0.05, **P  <  0.01 vs. the corresponding controls

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