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Fig. 2 | Cancer Cell International

Fig. 2

From: RAMS11 promotes CRC through mTOR-dependent inhibition of autophagy, suppression of apoptosis, and promotion of epithelial-mesenchymal transition

Fig. 2

Downregulation of RAMS11 inhibited CRC cells proliferation, growth, and migration. A CCK-8 assay was performed to evaluate the proliferation of HCT-116 and SW480 cells after Dsi-RAMS11 transfection. Downregulation of RAMS11 significantly reduced both cells proliferation at 24, 48, 72, and 96 h of the experiments. B The number of colonies were also significantly decreased in both cells after Dsi-RAMS11. C The wound healing migration assay was performed to measure the migration index of HCT-116 and SW480 cells after Dsi-RAMS11. It shown that after RAMS11 knockdown, the migration index of HCT-116 and SW480 cells were significantly increased at 24 and 48 h of experiments compared to Dsi-NC. The data was shown as mean ± SEM compared to Dsi-NC group. (*P < 0.05, **P < 0.01, and n = 4)

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Cancer Cell International

ISSN: 1475-2867

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