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Fig. 3 | Cancer Cell International

Fig. 3

From: RAMS11 promotes CRC through mTOR-dependent inhibition of autophagy, suppression of apoptosis, and promotion of epithelial-mesenchymal transition

Fig. 3

Downregulation of RAMS11 promoted autophagy in CRC cells. The autophagy marker proteins LC3B, p62, and Beclin-1 were measured using western blot in both HCT-116 A–D, and SW480 E–H cells. The Dsi-RAMS11 treated cells increased ratio of LC3-II/LC3-I, and Beclin-1 in both HCT-116 and SW480 cells, whereas reduced p62 expressions. The data was shown as relative expression mean ± SEM compared to Dsi-NC group using GAPDH as housekeeping gene. (*P < 0.05, **P < 0.01, and n = 4)

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Cancer Cell International

ISSN: 1475-2867

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