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Fig. 4 | Cancer Cell International

Fig. 4

From: RAMS11 promotes CRC through mTOR-dependent inhibition of autophagy, suppression of apoptosis, and promotion of epithelial-mesenchymal transition

Fig. 4

Downregulation of RAMS11 reduced the expression of apoptosis suppressors. The key apoptosis markers Bcl-2, Bcl-xL, and procaspase-9 were evaluated by western blotting in A–D HCT-116 and E–H SW480 cells. Downregulation of RAMS11 significantly reduced the expressions of Bcl-2, Bcl-xL, and procaspase-9 in both HCT-116 and SW480 cells compared to negative control Dsi-NC. The data was shown as relative expression mean ± SEM compared to Dsi-NC group using β-actin as housekeeping gene. (*P < 0.05, **P < 0.01, and n = 4)

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Cancer Cell International

ISSN: 1475-2867

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