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Table 3 Application of chitosan nanoparticles in the nano-drug delivery system in pre-clinical and clinical studies

From: Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

Compound used in combination with chitosan nanoparticles

Features

References

Pre-clinical studies

 Bupivacaine

↑ Anaesthetic effects of bupivacaine

[150]

 Paclitaxel

↑Tumour-targeting effect

[136]

 Prothionamide

↑ Treatment of tuberculosis

[148]

 Hydrocortisone

↑Elastic connectivity of tissues which improves atopic dermatitis

[149]

 Curcumin

↑ Curcumin’s anticancer activity against colon and breast cancer cells

[145]

 Albumin

↑ Oral delivery of albumin

[146]

 Ocimum gratissimum essential oil

↑Antibacterial activity

↑anticancer activity against breast cancer

[144]

 Triphosphate

Improve delivery and health effects

[143]

 RGD peptides

Localize to the tumour vasculature

↑antiangiogenic effects

[142]

Clinical studies

 Morphine

Improve pain medications of morphine

[151]

 Doxorubicin

↓ Doxorubicin toxicity

↓ tumour growth

[141]