Serum EA-IgA and d-dimer, but not VCA-IgA, are associated with prognosis in patients with nasopharyngeal carcinoma: a meta-analysis

Table 1 Main characteristics of the nine studies included in the final analysis

Study	Country	Area	Patients	Gender		Mean age	TNM stage	Median follow-up time (month)	Markers	Survival outcomes	Quality score
Study	Country	Area	Patients	Male	Female	Mean age	TNM stage	Median follow-up time (month)	Markers	Survival outcomes	Quality score
He et al. [16]	China	Guangzhou	511	–	–	–	I–IV	45.2	d-Dimer, EBV-DNA	OS, DMFS	⭐⭐⭐⭐⭐⭐
Chen et al. [14]	China	Guangzhou	717	533	184	47	I–IV	31	d-Dimer, EBV-DNA, VCA-IgA, EA-IgA	OS, DMFS, DFS	⭐⭐⭐⭐⭐⭐⭐⭐
Xu et al. [21]	China	Guangzhou	703	539	164	–	I–IV	120	VCA-IgA, EA-IgA	OS	⭐⭐⭐⭐⭐⭐⭐
Feng et al. [15]	China	Guangzhou	143	118	24	49.6	I–IV	–	VCA-IgA, EA-IgA	OS	⭐⭐⭐⭐⭐⭐⭐⭐
Jin et al. [18]	China	Guangzhou	799	664	135	45.4	I–IV	15.4	VCA-IgA, EBV-DNA	OS	⭐⭐⭐⭐⭐⭐
Twu et al. [20]	China	Taiwan	114	87	27	46	I–IV	46	VCA-IgA, VCA-IgG, EBV-DNA	OS, RFS	⭐⭐⭐⭐⭐⭐
Cao et al. [13]	China	Guangzhou	198	156	42	44.5	I–IV	51.5	VCA-IgA, EA-IgA	OS	⭐⭐⭐⭐⭐⭐
Yao et al. [22]	China	Guangzhou	334	251	83	45	I–IV	–	VCA-IgA, EA-IgA	OS, DMFS, PFS, LRFS	⭐⭐⭐⭐⭐⭐
Jin et al. [17]	China	Xuzhou	164	117	47	–	I–IV	49.2	VCA-IgA, EA-IgA, EBV-DNA	OS, DMFS, DFS, LRFS	⭐⭐⭐⭐⭐⭐

OS overall survival, PFS progression-free survival, DMFS distant metastasis-free survival, LRFS local–regional failure survival, MFS metastasis-free survival, DFS disease-free survival, RFS relapse-free survival

ISSN: 1475-2867