Upregulated CD58 is associated with clinicopathological characteristics and poor prognosis of patients with pancreatic ductal adenocarcinoma

Table 4 The correlation of CD58 with immune-related, EMT-related, CSC-related markers

Types	Markers	TIMER		GEPIA
Types	Markers	R	p-value	R	p-value
Immune cell	CD45 (PTPRC)	0.050	0.510	0.037	0.620
T cell (general)	CD3D	− 0.008	0.911	− 0.026	0.730
	CD3E	− 0.002	0.982	− 0.013	0.860
	CD3G	0.027	0.721	− 0.028	0.710
CD4⁺ T cell	CD4	0.088	0.242	0.075	0.320
	FOXP3	0.057	0.451	0.066	0.380
CD8⁺ T cell	CD8A	− 0.001	0.986	− 0.200	0.790
	CD8B	0.019	0.799	0.009	0.910
B cell	CD19	0.030	0.695	0.022	0.770
	CD79A	− 0.018	0.814	− 0.046	0.540
Monocyte	CD86	0.158	*	0.150	*
	CD115 (CSF1R)	0.043	0.568	0.053	0.480
Neutrophil	CD66b (CEACAM8)	0.182	*	0.190	*
	CD11b (ITGAM)	0.255	***	0.240	**
	CCR7	0.013	0.860	− 0.003	0.97
TAM	CD68	0.288	***	0.290	***
	CCL2	− 0.053	0.477	− 0.051	0.500
M1 Macrophage	iNOS (NOS2)	0.086	0.249	0.110	0.130
	HLA-DRB1	0.067	0.375	0.089	0.230
M2 Macrophage	CD163	0.088	0.243	0.110	0.140
	CD204 (MSR1)	0.138	0.067	0.140	0.057
	CD206 (MRC1)	0.066	0.382	0.058	0.440
NK cell	CD56 (NCAM1)	− 0.353	***	− 0.230	**
	KIR2DL1	− 0.043	0.564	− 0.050	0.510
	KIR3DL1	− 0.106	0.158	− 0.130	0.081
	KIR2DS4	0.036	0.633	0.027	0.720
DC	S100A1	− 0.148	*	− 0.160	*
	S100B	− 0.030	0.686	− 0.028	0.710
EMT-related	Vimentin (VIM)	0.196	**	0.210	**
	E-Cadherin (CDH1)	0.506	***	0.540	***
	Twist (TWIST1)	0.313	***	0.320	***
	Snail (SNAI1)	0.157	*	0.170	*
	N-Cadherin (CDH2)	0.032	0.670	0.051	0.500
CSC-related	CD133 (PROM1)	0.334	***	0.350	***
	OCT4 (POU5F1)	0.407	***	0.420	***
	KLF4	0.377	***	0.400	***
	NANOG	0.060	0.428	0.170	*
	CD24	0.149	*	0.140	0.059
	ALDH1A1	− 0.044	0.560	− 0.047	0.530
	SOX2	− 0.032	0.673	− 0.021	0.780

N = 178
R Spearman’s rho value, TAM tumor-associated macrophage, NK cell natural killer cell, EMT epithelial–mesenchymal transition, CSC cancer stem cell
*p < 0.05, **p < 0.01, ***p < 0.001

ISSN: 1475-2867