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Fig. 3 | Cancer Cell International

Fig. 3

From: The prognostic outcome of ‘type 2 diabetes mellitus and breast cancer’ association pivots on hypoxia-hyperglycemia axis

Fig. 3

HIF1 signaling. HIF1 is a dimeric transcription factor composed of an oxygen concentration sensitive HIF1-α subunit and a constitutively present HIF1-β subunit. Under hypoxic conditions, HIF1-α stabilizes and forms a dimer with HIF1-β subunit to transcriptionally activate the expression of HIF1 target genes. HIF1 has also been shown to be activated under normoxic conditions by various factors as depicted [108,109,110,111,112,113,114,115,116]

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