Fig. 4

Transitions in cell signaling associated with diabetes induced breast tumorigenesis. HIF1 signaling not only cross-talks with Insulin but also other crucial pathways implicated in diabetes mellitus and breast cancer. Key players (identified by purple circles) along with the states contributing to their regulation (blue border-white box) and in turn feed into major signaling pathways (blue box) involved in the diabetes to breast cancer transition [44, 125,126,127,128]