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Table 2 Univariate and multivariate analysis of OS in the training cohort

From: Derivation and validation of a lipid-covered prognostic model for mature T-cell lymphomas

Basic results

Univariate analysis

Multivariate analysis

B

SE

HR (95% CI)

P-value

B

SE

HR (95% CI)

P-value

Age, ≥ 60 vs. < 60, years

0.937

0.248

2.553 (1.570, 4.151)

0.000

    

Sex, male vs. female

− 0.039

0.267

0.961 (0.569, 1.623)

0.883

    

ECOG score, ≥ 2 vs. < 2

1.311

0.259

3.710 (2.232, 6.167)

0.000

    

BM involvement, presence vs. absence

0.988

0.261

2.687 (1.612, 4.480)

0.000

    

Extranodal sites, ≥ 2 vs. < 2

1.991

0.293

7.326 (4.125, 13.010)

0.000

0.892

0.424

2.439 (1.062, 5.602)

0.036

Ann Arbor stage, III/IV vs. I/II

1.209

0.296

3.350 (1.874, 5.988)

0.000

    

B symptoms, presence vs. absence

0.446

0.264

1.563 (0.931, 2.623)

0.091

    

LDH, ≥ 250 vs. < 250, U/L

1.305

0.256

3.687 (2.231, 6.090)

0.000

    

β2-MG, ≥ 3 vs. < 3, mg/L

2.635

0.364

13.939 (6.835, 28.425)

0.000

1.427

0.480

4.165 (1.625, 10.674)

0.003

TC, ≤ 3.58 vs. > 3.58, mmol/L

2.029

0.267

7.604 (4.507, 12.831)

0.000

1.205

0.335

3.338 (1.732, 6.434)

0.000

HDL-C, ≤ 0.95 vs. > 0.95, mmol/L

0.860

0.246

2.364 (1.460, 3.828)

0.000

    

TG, > 1.42 vs. ≤ 1.42, mmol/L

0.880

0.248

2.412 (1.483, 3.922)

0.000

    

IPI 4/5 vs. 3 vs. 2 vs. 0/1

0.770

0.110

2.160 (1.740, 2.682)

0.000

    
  1. ECOG Eastern Cooperative Oncology Group, BM bone marrow, LDH lactate dehydrogenase, β2-MG beta-2 microglobulin, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, TG triglycerides, IPI International Prognostic Index, OS overall survival, PFS progression-free survival, B regression coefficient, SE standard error, HR hazard ratio, CI confidence interval
  2. Significant P-value < 0.05 is shown in bold