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Table 2 Univariate and multivariate analysis of OS in the training cohort

From: Derivation and validation of a lipid-covered prognostic model for mature T-cell lymphomas

Basic results Univariate analysis Multivariate analysis
B SE HR (95% CI) P-value B SE HR (95% CI) P-value
Age, ≥ 60 vs. < 60, years 0.937 0.248 2.553 (1.570, 4.151) 0.000     
Sex, male vs. female − 0.039 0.267 0.961 (0.569, 1.623) 0.883     
ECOG score, ≥ 2 vs. < 2 1.311 0.259 3.710 (2.232, 6.167) 0.000     
BM involvement, presence vs. absence 0.988 0.261 2.687 (1.612, 4.480) 0.000     
Extranodal sites, ≥ 2 vs. < 2 1.991 0.293 7.326 (4.125, 13.010) 0.000 0.892 0.424 2.439 (1.062, 5.602) 0.036
Ann Arbor stage, III/IV vs. I/II 1.209 0.296 3.350 (1.874, 5.988) 0.000     
B symptoms, presence vs. absence 0.446 0.264 1.563 (0.931, 2.623) 0.091     
LDH, ≥ 250 vs. < 250, U/L 1.305 0.256 3.687 (2.231, 6.090) 0.000     
β2-MG, ≥ 3 vs. < 3, mg/L 2.635 0.364 13.939 (6.835, 28.425) 0.000 1.427 0.480 4.165 (1.625, 10.674) 0.003
TC, ≤ 3.58 vs. > 3.58, mmol/L 2.029 0.267 7.604 (4.507, 12.831) 0.000 1.205 0.335 3.338 (1.732, 6.434) 0.000
HDL-C, ≤ 0.95 vs. > 0.95, mmol/L 0.860 0.246 2.364 (1.460, 3.828) 0.000     
TG, > 1.42 vs. ≤ 1.42, mmol/L 0.880 0.248 2.412 (1.483, 3.922) 0.000     
IPI 4/5 vs. 3 vs. 2 vs. 0/1 0.770 0.110 2.160 (1.740, 2.682) 0.000     
  1. ECOG Eastern Cooperative Oncology Group, BM bone marrow, LDH lactate dehydrogenase, β2-MG beta-2 microglobulin, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, TG triglycerides, IPI International Prognostic Index, OS overall survival, PFS progression-free survival, B regression coefficient, SE standard error, HR hazard ratio, CI confidence interval
  2. Significant P-value < 0.05 is shown in bold