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Table 1 Pancreas tumor organoids culture system established for drug and biomarker screen

From: A pancreas tumor derived organoid study: from drug screen to precision medicine

Tissue

Species

Matrix

Trans-plantation

Drug testing

Biomarker screen

References

Nomal pancreas

PanIN

PDAC

Murine

Human

Embedded in Matrigel

Generation of PDAC and

PanIN

Yes

Yes

[9]

[24]

[27, 28]

[30]

iPSCs

PDAC

Human

Media and Matrigel

Generation primary tumor

Yes

Yes

[25]

PDAC

Murine

Human

Media and Matrigel

–

Yes

Yes

[34]

[89]

Neonatal tissue

PDAC

iPSCs

Murine

Human

Air-liquid interface on Matrigel

Generation of PDAC

Yes

Yes

[32]

  1. PanIN pancreas intraepithelial neoplasia, PDAC pancreas ductal adenocarcinoma, iPSCs induced pluripotent stem cells