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Table 1 Pancreas tumor organoids culture system established for drug and biomarker screen

From: A pancreas tumor derived organoid study: from drug screen to precision medicine

Tissue Species Matrix Trans-plantation Drug testing Biomarker screen References
Nomal pancreas
PanIN
PDAC
Murine
Human
Embedded in Matrigel Generation of PDAC and
PanIN
Yes Yes [9]
[24]
[27, 28]
[30]
iPSCs
PDAC
Human Media and Matrigel Generation primary tumor Yes Yes [25]
PDAC Murine
Human
Media and Matrigel Yes Yes [34]
[89]
Neonatal tissue
PDAC
iPSCs
Murine
Human
Air-liquid interface on Matrigel Generation of PDAC Yes Yes [32]
  1. PanIN pancreas intraepithelial neoplasia, PDAC pancreas ductal adenocarcinoma, iPSCs induced pluripotent stem cells