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Fig. 5 | Cancer Cell International

Fig. 5

From: Upregulation of ARNTL2 is associated with poor survival and immune infiltration in clear cell renal cell carcinoma

Fig. 5

ARNTL2 was upregulated in ccRCC and knockdown of ARNTL2 inhibits ccRCC cells tumorigenicity. a The IHC staining of ARNTL2 in normal kidney tissue and kidney cancer tissue were shown (HPA Antibody ID: HPA059074; scale bars, 100 μm). b Western blot assay showing the elevated expression of ARNTL2 in ccRCC cell lines (786-O and Caki-1) compared to normal kidney cell line (HK-2). c Western blot assay showing the decreased expression of ARNTL2 in ccRCC cell lines after treatment with si-ARNTL2. d Colony formation assay demonstrates lacked ARTNL2 suppressed colony formation ability of ccRCC cell lines. e The Wound healing assay indicates depletion of ARNTL2 impaired the wound healing efficacy of ccRCC cell lines. **, p < 0.01; ***, p < 0.001

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Cancer Cell International

ISSN: 1475-2867

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