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Fig. 2 | Cancer Cell International

Fig. 2

From: Targeting DNAJC19 overcomes tumor growth and lung metastasis in NSCLC by regulating PI3K/AKT signaling

Fig. 2

The inhibition of cell growth, viability, apoptosis, migration and invasion abilities in A549 and NCI-H1299 NSCLC cells treated with shDNAJC19 in vitro. A Designed shRNA significantly inhibits DNAJC19 protein expression in both lung cancer cells. B ShDNAJC19 markedly decreases the cell growth through Celigo. C ShDNAJC19 obviously inhibits the cell viability through MTT. D, E Representative images and semiquantitative analysis of cell migration, and shDNAJC19 markedly decreases the cell migration ability. F, G Representative images and semiquantitative analysis of cell invasion. ShDNAJC19 markedly decreases the cell invasion ability. H ShDNAJC19 significantly increases the cell apoptosis using Annexin V-APC kit. I Apoptotic related protein expressions in A549 cells with treatment of DNAJC19 shRNA using western blotting. The data were described as mean ± SD. *P < 0.05, **P < 0.01,***P < 0.001, as compared with the indicated group

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