Skip to main content
Fig. 4 | Cancer Cell International

Fig. 4

From: Targeting DNAJC19 overcomes tumor growth and lung metastasis in NSCLC by regulating PI3K/AKT signaling

Fig. 4

PI3K/AKT pathway is regulated by DNAJC19. A The related proteins were investigated in A549 cells treated with shDNAJC19 or shRNA control through western blotting. B Lentiviral-mediated AKT (Lv-AKT) overexpression in A549 cells with treatment of DNAJC19 shRNA using western blotting. C The growth was strongly restored by overexpression of AKT in A549 cells concurrently treated with shDNAJC19 via Celigo assay. D The cell viability was rescued by AKT overexpression in A549 cells with the concurrent treatment with shDNAJC19 using MTT assay. E, F The migration ability of A549 cells was strongly enhanced by simultaneous AKT overexpression and DNAJC19 knockdown. Data are shown as mean ± SD. **P < 0.01, when in contrast with the indicated group

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us