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Fig. 5 | Cancer Cell International

Fig. 5

From: Targeting DNAJC19 overcomes tumor growth and lung metastasis in NSCLC by regulating PI3K/AKT signaling

Fig. 5

shDNAJC19 significantly decreased tumor growth and metastasis of NSCLC in Balb/c nude mice. A Xenograft samples from A549 cells with transfection of shDNAJC19 or shRNA control. B The weight of xenograft tumor from A549 cells with transfection of shDNAJC19 or shRNA control. C Tumor volume of xenografts from A549 cells with transfection of shDNAJC19 or shRNA control. D Immunohistochemistry results for DNAJC19, PI3K and AKT expressions in xenograft tissues, respectively. E, F Tumor metastasis model from IVIS images and semiquantitative analysis. ShDNAJC19 had fewer average metastatic tumor lesions in each mouse and fewer mice with metastasis were observed in the shDNAJC19 group than in the shCtrl group. G The representative photos for the metastasis lesion using HE staining, and the lesion was definitely observed in lung tissue in shControl group (red rectangle). H The ki-67 expressions in metastasis lesions are strongly high in shControl group than in shDNAJC19 group using immunohistochemistry. Data are shown as mean ± SD. **P < 0.01, ***p < 0.001, when in contrast with the indicated group

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