Table 2 Exosomal RNAs involved in the development and progression in PaCa
From: The significance of exosomal RNAs in the development, diagnosis, and treatment of pancreatic cancer
RNA Type | Molecules | Origin | Effects | Targets | Refs. |
|---|---|---|---|---|---|
miRNA | miRNA-222 | TDEs | Proliferation ↑ Invasion ↑ | p27/Akt | [61] |
miRNA-501-3p | TAMs | Tumorigenesis ↑ Metastasis ↑ | TGFBR3/ TGF-β | [62] | |
miRNA-5703 | PSCs | Proliferation ↑ | CMTM4/PI3K/Akt | [63] | |
miRNA-3607-3p | NK cells | Proliferation ↓ Migration ↓ Invasion ↓ | IL-26 | [64] | |
miRNA-1231 | BM-MSCs | Proliferation ↓ Migration ↓ Invasion ↓ | Not mentioned | [65] | |
miRNA-126-3p | BM-MSCs | Proliferation ↓ Migration ↓ Invasion ↓ | ADAM9 | [66] | |
miRNA-27a | TDEs | Angiogenesis ↑ | BTG2 | [68] | |
miRNA-10a-5p | CAFs | Migration ↑ Invasion ↑ | VDR | [71] | |
miRNA-21 | CAFs | Migration ↑ Invasion ↑ | Not mentioned | [72] | |
miRNA-221 | CAFs | Migration ↑ Invasion ↑ | NF-κ B/KRAS | [72] | |
miRNA-21-5p | PSCs | Proliferation ↑ Migration ↑ | Not mentioned | [73] | |
miRNA-451a | PSCs | Proliferation ↑ Migration ↑ | Not mentioned | [73] | |
miRNA-125b-5p | TDEs | Migration ↑ Invasion ↑ EMT ↑ | MEK2/ERK2 | [85] | |
miRNA-301a | TDEs | Migration ↑ Invasion ↑ EMT ↑ | PTEN/PI3Kγ | [86] | |
miRNA-203 | TDEs | Immune Escape ↑ | TNF-α/IL-12/TLR4 | [94] | |
miRNA-212-3p | TDEs | Immune Escape ↑ | RFXAP/ MHC II | [95] | |
miRNA-210 | TDEs | GEM-resistance ↑ | mTOR | [99] | |
miRNA-106b | CAFs | GEM-resistance ↑ | TP53INP1 | [100] | |
miRNA-365 | TAMs | GEM-resistance ↑ | NTP/CDA | [101] | |
miRNA-155 | TDEs | GEM-resistance ↑ | SOD/CAT/DCK | [103] | |
miRNA-194-5p | TDEs | Radiotherapy-resistance ↑ | E2F3 | [105] | |
lncRNA | UCA1 | TDEs | Angiogenesis ↑ | miRNA-96-5p/AMOTL2 | [69] |
SBF2-AS1 | TAMs | Migration ↑ Invasion ↑ Metastasis ↑ | miRNA-122-5p/XIAP | [74] | |
HULC | TAMs | EMT ↑ Invasion ↑ Migration ↑ | Not mentioned | [75] | |
NONHSAT105177 | TDEs | Proliferation ↓ Migration ↓ EMT ↓ | Clusterin | [76] | |
Sox2ot | TDEs | Invasion ↑ Metastasis ↑ EMT ↑ | miRNA-200 family/ Sox2 | [77] | |
circRNA | PDE8A | TDEs | Invasion ↑ | miRNA-338/MACC1/MET | [78] |
IARS | TDEs | Metastasis ↑ | HUVECs | [79] | |
hsa_circ_0002130 | TDEs | Radiotherapy-resistance ↑ | Not mentioned | [106] |