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Table 2 Exosomal RNAs involved in the development and progression in PaCa

From: The significance of exosomal RNAs in the development, diagnosis, and treatment of pancreatic cancer

RNA Type Molecules Origin Effects Targets Refs.
miRNA miRNA-222 TDEs Proliferation ↑
Invasion ↑
p27/Akt [61]
miRNA-501-3p TAMs Tumorigenesis ↑
Metastasis ↑
TGFBR3/ TGF-β [62]
miRNA-5703 PSCs Proliferation ↑ CMTM4/PI3K/Akt [63]
miRNA-3607-3p NK cells Proliferation ↓
Migration ↓
Invasion ↓
IL-26 [64]
miRNA-1231 BM-MSCs Proliferation ↓
Migration ↓
Invasion ↓
Not mentioned [65]
miRNA-126-3p BM-MSCs Proliferation ↓
Migration ↓
Invasion ↓
ADAM9 [66]
miRNA-27a TDEs Angiogenesis ↑ BTG2 [68]
miRNA-10a-5p CAFs Migration ↑
Invasion ↑
VDR [71]
miRNA-21 CAFs Migration ↑
Invasion ↑
Not mentioned [72]
miRNA-221 CAFs Migration ↑
Invasion ↑
NF-κ B/KRAS [72]
miRNA-21-5p PSCs Proliferation ↑
Migration ↑
Not mentioned [73]
miRNA-451a PSCs Proliferation ↑
Migration ↑
Not mentioned [73]
miRNA-125b-5p TDEs Migration ↑
Invasion ↑
EMT ↑
MEK2/ERK2 [85]
miRNA-301a TDEs Migration ↑
Invasion ↑
EMT ↑
PTEN/PI3Kγ [86]
miRNA-203 TDEs Immune Escape ↑ TNF-α/IL-12/TLR4 [94]
miRNA-212-3p TDEs Immune Escape ↑ RFXAP/ MHC II [95]
miRNA-210 TDEs GEM-resistance ↑ mTOR [99]
miRNA-106b CAFs GEM-resistance ↑ TP53INP1 [100]
miRNA-365 TAMs GEM-resistance ↑ NTP/CDA [101]
miRNA-155 TDEs GEM-resistance ↑ SOD/CAT/DCK [103]
miRNA-194-5p TDEs Radiotherapy-resistance ↑ E2F3 [105]
lncRNA UCA1 TDEs Angiogenesis ↑ miRNA-96-5p/AMOTL2 [69]
SBF2-AS1 TAMs Migration ↑
Invasion ↑
Metastasis ↑
miRNA-122-5p/XIAP [74]
HULC TAMs EMT ↑
Invasion ↑
Migration ↑
Not mentioned [75]
NONHSAT105177 TDEs Proliferation ↓
Migration ↓
EMT ↓
Clusterin [76]
Sox2ot TDEs Invasion ↑
Metastasis ↑
EMT ↑
miRNA-200 family/ Sox2 [77]
circRNA PDE8A TDEs Invasion ↑ miRNA-338/MACC1/MET [78]
IARS TDEs Metastasis ↑ HUVECs [79]
hsa_circ_0002130 TDEs Radiotherapy-resistance ↑ Not mentioned [106]