The significance of exosomal RNAs in the development, diagnosis, and treatment of pancreatic cancer

Table 3 Exosomal RNAs as biomarkers for Paca

RNA Type	Molecules	Origin	Potential functions	Refs.
miRNA	miRNA‑21	Peripheral blood	Early diagnosis/tumor stage/survival evaluation	[116,117,118,119]
	miRNA-210	Peripheral blood	Early diagnosis/tumor stage	[116]
	miRNA-10b	Peripheral blood	Early diagnosis	[117, 120]
	miRNA-1246	Peripheral blood	Early diagnosis	[121]
	miRNA-451a	Peripheral blood	Tumor stage/survival evaluation	[122]
	miRNA-222	Peripheral blood	Tumor stage/survival evaluation	[61]
	miRNA-4525	Portal vein blood	Recurrence prediction/survival evaluation	[124]
	miRNA-451a	Portal vein blood	Recurrence prediction/survival evaluation	[124]
	miRNA-21	Portal vein blood	Recurrence prediction/survival evaluation	[124]
	miRNA-21	Pancreatic juice	Early diagnosis	[125]
	miRNA-155	Pancreatic juice	Early diagnosis	[125]
	miRNA-1246	Salivary	Early diagnosis	[126]
	miRNA-4644	Salivary	Early diagnosis	[126]
lncRNA	Sox2ot	Peripheral blood	Tumor stage/survival evaluation	[77]
	HULC	Peripheral blood	Early diagnosis	[75]
	CRNDE	Peripheral blood	Early diagnosis	[136]
	MALAT-1	Peripheral blood	Early diagnosis	[136]
circRNA	PDE8A	Peripheral blood	Tumor stage/survival evaluation	[78]
circRNA	IARS	Peripheral blood	Tumor stage/survival evaluation	[79]
mRNA	WASF2	Peripheral blood	Early diagnosis/tumor stage/	[139]
mRNA	GPC1	Peripheral blood	Early diagnosis/tumor stage/	[140]

ISSN: 1475-2867