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Fig. 1 | Cancer Cell International

Fig. 1

From: JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4

Fig. 1

Elevated JOSD1 indicates unfavorable prognosis in HNSCC. a The Venn diagrams based on TCGA and GEO databases identified significantly upregulated DUBs in HNSCC, including JOSD1, PSMD14, SENP5, TNFAIP3, UCK2, UFD1L. b The expression of JOSD1 was increased in HNSCC compared to normal tissues in three independent GEO datasets (GSE13601, GSE33205, GSE37991). N, normal tissue. C, cancerous specimen. Data, mean ± SD. c The representative images of IHC staining to assess the expression of JOSD1 in HNSCC tissues. Scale bar, 50 μm. d The IHC results showed that JOSD1 was overexpressed in chemoresistant HNSCC samples relative to the sensitive ones. Scale bar, 50 μm. e Kaplan–Meier survival curve revealed that the high expression of JOSD1 predicted poor prognosis of patients with HNSCC

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