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Fig. 5 | Cancer Cell International

Fig. 5

From: OIP5-AS1 contributes to the development in endometrial carcinoma cells by targeting miR-152-3p to up-regulate SLC7A5

Fig. 5

SLC7A5 overexpression can rescue the effects of OIP5-AS1 down-regulation on the development of EC cells. A These mRNAs expressions were detected by RT-qPCR in cells after the overexpression of miR-152-3p. B Bioinformatics presentation of miR-152-3p and SLC7A5 binding sites. C RIP assay testified OIP5-AS1, miR-152-3p and SLC7A5 coexisted in RNA induced silencing complexes (RISCs). D Luciferase activity of SLC7A5-WT/Mut in response to NC mimics or miR-152-3p mimics in EC cells as well as the addition of pcDNA3.1-OIP5-AS1 into cells. E Overexpressed SLC7A5 was validated in RT-qPCR. The influence of sh-OIP5-AS1#1 on EC cells proliferation (F), apoptosis (G, H), and migration as well as invasion (I-J) and EMT (K) was rescued by overexpression of SLC7A5. **Pā€‰<ā€‰0.01

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