Table 1 Studies investigated the antitumor roles of quercetin on human osteosarcoma
Dose(s) | Duration of incubation | Quercetin’s effect | Cell line(s) | Ref. |
|---|---|---|---|---|
80 and 100 µM | 48 h | Inhibits proliferation and metastasis through suppressing PTHR1 | U2OS and Saos-2 | [92] |
25 or 50 µM | 18 h | Suppresses proliferation and migration while inducing apoptosis | 143B | [90] |
25, 50 and 100 µM | 12 and 24 h | Suppresses metastatic lung tumors | HOS and MG-63 | [91] |
10, 25 or 50 µM | 48 h | Induces apoptosis by mitochondrial dysfunction and dephosphorylation of Akt | U2OS/MTX300 | [94] |
– | – | Reduces mitochondrial membrane potential and release of mitochondrial cytochrome c to cytosol while dephosphorylating Akt | U2OS/MTX300 | [95] |
50, 100 and 200 µM | 24 h | Induces autophagy by the ROS-NUPR1 pathway | MG-63 | [97] |
10, 100, 200, 500 and 1000 µM | 48 h | Induces apoptosis and cell cycle arrest at G(1)/S | HOS | [96] |
20, 40, 80, 160, 240 and 320 µM | 48 h | Induces apoptosis via a mitochondrial-dependent pathway and reduces cell viability | MG-63 | [93] |
– | – | Downregulated glucocorticoid receptors in osteosarcoma cells | HOS-8603 | [89] |
5 µM | 24 h | Improves cisplatin sensitivity by miR-217/KRAS axis | 143B | [98] |
50 µM | 48 h | Leads to the alteration in G1/S phase and reduction in cyclin D1 in U2OSPt | U2OS and U2OSPt | [99] |