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Table 1 Studies investigated the antitumor roles of quercetin on human osteosarcoma

From: Anti-cancer properties of quercetin in osteosarcoma

Dose(s) Duration of incubation Quercetin’s effect Cell line(s) Ref.
80 and 100 µM 48 h Inhibits proliferation and metastasis through suppressing PTHR1 U2OS and Saos-2 [92]
25 or 50 µM 18 h Suppresses proliferation and migration while inducing apoptosis 143B [90]
25, 50 and 100 µM 12 and 24 h Suppresses metastatic lung tumors HOS and MG-63 [91]
10, 25 or 50 µM 48 h Induces apoptosis by mitochondrial dysfunction and dephosphorylation of Akt U2OS/MTX300 [94]
Reduces mitochondrial membrane potential and release of mitochondrial cytochrome c to cytosol while dephosphorylating Akt U2OS/MTX300 [95]
50, 100 and 200 µM 24 h Induces autophagy by the ROS-NUPR1 pathway MG-63 [97]
10, 100, 200, 500 and 1000 µM 48 h Induces apoptosis and cell cycle arrest at G(1)/S HOS [96]
20, 40, 80, 160, 240 and 320 µM 48 h Induces apoptosis via a mitochondrial-dependent pathway and reduces cell viability MG-63 [93]
Downregulated glucocorticoid receptors in osteosarcoma cells HOS-8603 [89]
5 µM 24 h Improves cisplatin sensitivity by miR-217/KRAS axis 143B [98]
50 µM 48 h Leads to the alteration in G1/S phase and reduction in cyclin D1 in U2OSPt U2OS and U2OSPt [99]