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Fig. 1 | Cancer Cell International

Fig. 1

From: Elevated exosome-derived miRNAs predict osimertinib resistance in non-small cell lung cancer

Fig. 1

Isolation and identification of exosomes. A The drug-resistant strain, H1975-OR, was obtained by continuous exposure of H1975 to osimertinib for 6 months. After incubating H1975-OR and H1975 cells with different concentrations of osimertinib for 72 h, the cell viability was measured using the MTT method. B The average IC50 values in H1975 and H1975-OR were 4636 nM and 12,101 nM, respectively, and the difference was statistically significant (p = 0.0215). C The exosomes (30–150 nm) extracted from the H1975, H1975-OR cell supernatant, the osimertinib-sensitive and osimertinib-resistant patients serum were observed using electron microscopy. Scale = 200 nm. D Exosomes were validated by protein analysis in western blot

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