Fig. 3
From: Elevated exosome-derived miRNAs predict osimertinib resistance in non-small cell lung cancer
MiR-184 and miR-3913-5p elevated expression in exosomes after osimertinib resistance. A Overlaid analysis of Wayne maps of exosomal miRNAs up-regulated and B down-regulated exosomal miRNAs in the drug-resistant group compared to that in the sensitive group. C q-PCR exosome miR-184 expression levels in patients with osimertinib-resistant NSCLC (OR, n = 27) and patients without resistance (GR, n = 37), * p < 0.05. D Serum exosomal miR-3913-5p expression levels in patients with osimertinib-resistant NSCLC (OR, n = 27) and osimertinib-sensitive patients (GR, n = 36), * p < 0.05. E Changes in the expression levels of the two exosomal miRNAs before and after resistance to osimertinib, **p < 0.01. F ROC curves for miR-184 (green), miR-3913-5p (blue), and the two miRNAs (red), respectively