Elevated exosome-derived miRNAs predict osimertinib resistance in non-small cell lung cancer

Table 2 Correlation between serum exosomal miR-3913-5p expression levels in patients with NSCLC and their clinicopathological characteristics. ( p* < 0.05)

Clinicopathological parameters	Number of patients(%)	Exosomal miR-3913-5p
Clinicopathological parameters	Number of patients(%)	Low	High	P
Age(years), Median				0.714
< 60	32	25	7
≥ 60	31	23	8
Gender				0.427
Male	28	20	8
Female	35	28	7
Smoking history				0.321
Never smoking	48	38	10
Now/once smoking	15	10	5
ECOG Score				0.064
0–1	52	42	10
≥ 2	11	6	5
Primary tumor				0.64
≤ 4 cm	18	13	5
> 4 cm	45	35	10
TNM				0.045*
I–IVA	24	15	9
IVB	39	33	6
PLT				0.024*
Low(≤ 146)	13	13	0
High(> 146)	50	35	15
LDH				0.427
Low(≤ 199)	28	20	8
High(> 199)	35	28	7
CEA				0.045*
Low(≤ 8.605)	24	15	9
High(> 8.605)	39	33	6
Distant metastasis				0.049*
No	17	10	7
Yes	46	38	8
Contralateral lung metastasis				0.434
No	24	17	7
Yes	39	31	8
Pleura metastasis				0.414
No	32	23	9
Yes	31	25	6
Bone metastasis				0.03*
No	23	14	9
Yes	40	34	6
Brain metastasis				0.112
No	35	24	11
Yes	28	24	4

ISSN: 1475-2867