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Table 4 Molecular mechanisms of PCAT6 oncogenesis in various cancers

From: PCAT6 may be a new prognostic biomarker in various cancers: a meta-analysis and bioinformatics analysis

Tumor type Expression Molecular mechanisms References
Ovarian cancer High Promotes ovarian carcinogenesis and progression by regulating PTEN, while suppression of PTEN expression counteracts the role of PCAT6 in ovarian cell carcinoma [23]
Cervical cancer High Promotes proliferation and metastasis of cervical cancer cells through regulation of the Wnt/ β-catenin pathway [26]
Colon cancer High Promote apoptosis in colon cancer cells by regulating the level of anti-apoptotic protein ARC [46]
Lung cancer High Reduces LATS2 promoter activity by binding to EZH2 leading to H3K27 trimethylation in the LATS2 promoter region, thereby affecting the proliferation and metastasis of non-small cell lung cancer cells [25]
High Influences the biological function of lung cancer cells by affecting the expression of p53 and c-Myc, key proteins that regulate cancer progression [17]
High Promotes proliferation, migration, and invasion of non-small cell lung cancer cells through regulation of miR-330-5p [37]
Pancreatic ductal carcinoma High Promotes the proliferation, migration, and invasion of pancreatic ductal carcinoma cells by secreting miR-185-5p to upregulate the expression of the cancer-related gene CBX2 [27]
Osteosarcoma High Progression of osteosarcoma is accelerated by regulating the miR-143-3p/ ZEB1 pathway [23]
High Activation of TGF-β pathway promotes osteosarcoma progression by sponging miR-185-5p and upregulating the expression of TGFBR1 and TGFBR2 [35]
High Promotes proliferation, migration, and invasion of osteosarcoma cells by suppressing p53 and p21 expression through promotion of MDM2 expression [33]
Stomach cancer High Promotes proliferation and metastasis of gastric cancer cells by endogenously competing with miR-30 to upregulate MKRN3 expression [39]
Bladder cancer High Promotes the progression of bladder cancer cells by targeting miR-513a-5p [43]
Glioblastoma High Upregulates IGF2BP1 expression by miR-513, by forming a PCAT6/ miR-513/ IGF2BP1 positive feedback loop, thus promoting the progression of glioblastoma [44]
Gastrointestinal mesenchymal tumor High Promotes proliferation of gastrointestinal mesenchymal tumor cells through miR-143-3p upregulation of PRDX5 [47]
Breast cancer High Promotes TNBC cell proliferation, migration, invasion, EMT, and angiogenesis, as well as tumor growth and metastasis via upregulation of VEGFR2 through sponging miR-4723-5p and recruiting USP14 [40]
High Silencing PCAT6 inhibits the proliferation of triple-negative breast cancer cells and promoted apoptosis by upregulating the expression of miR-185-5p and downregulating the expression of TPD52 [38]
Bile duct cancer High Inhibits cell proliferation and invasion by reducing miR-330-5p expression in bile duct cancer cells [42]
Pituitary adenoma High Promotes pituitary adenoma progression by targeting the miR-139-3p/ BRD4 axis [45]