|
Ovarian cancer
|
High
|
Promotes ovarian carcinogenesis and progression by regulating PTEN, while suppression of PTEN expression counteracts the role of PCAT6 in ovarian cell carcinoma
|
[23]
|
|
Cervical cancer
|
High
|
Promotes proliferation and metastasis of cervical cancer cells through regulation of the Wnt/ β-catenin pathway
|
[26]
|
|
Colon cancer
|
High
|
Promote apoptosis in colon cancer cells by regulating the level of anti-apoptotic protein ARC
|
[46]
|
|
Lung cancer
|
High
|
Reduces LATS2 promoter activity by binding to EZH2 leading to H3K27 trimethylation in the LATS2 promoter region, thereby affecting the proliferation and metastasis of non-small cell lung cancer cells
|
[25]
|
|
High
|
Influences the biological function of lung cancer cells by affecting the expression of p53 and c-Myc, key proteins that regulate cancer progression
|
[17]
|
|
High
|
Promotes proliferation, migration, and invasion of non-small cell lung cancer cells through regulation of miR-330-5p
|
[37]
|
|
Pancreatic ductal carcinoma
|
High
|
Promotes the proliferation, migration, and invasion of pancreatic ductal carcinoma cells by secreting miR-185-5p to upregulate the expression of the cancer-related gene CBX2
|
[27]
|
|
Osteosarcoma
|
High
|
Progression of osteosarcoma is accelerated by regulating the miR-143-3p/ ZEB1 pathway
|
[23]
|
|
High
|
Activation of TGF-β pathway promotes osteosarcoma progression by sponging miR-185-5p and upregulating the expression of TGFBR1 and TGFBR2
|
[35]
|
|
High
|
Promotes proliferation, migration, and invasion of osteosarcoma cells by suppressing p53 and p21 expression through promotion of MDM2 expression
|
[33]
|
|
Stomach cancer
|
High
|
Promotes proliferation and metastasis of gastric cancer cells by endogenously competing with miR-30 to upregulate MKRN3 expression
|
[39]
|
|
Bladder cancer
|
High
|
Promotes the progression of bladder cancer cells by targeting miR-513a-5p
|
[43]
|
|
Glioblastoma
|
High
|
Upregulates IGF2BP1 expression by miR-513, by forming a PCAT6/ miR-513/ IGF2BP1 positive feedback loop, thus promoting the progression of glioblastoma
|
[44]
|
|
Gastrointestinal mesenchymal tumor
|
High
|
Promotes proliferation of gastrointestinal mesenchymal tumor cells through miR-143-3p upregulation of PRDX5
|
[47]
|
|
Breast cancer
|
High
|
Promotes TNBC cell proliferation, migration, invasion, EMT, and angiogenesis, as well as tumor growth and metastasis via upregulation of VEGFR2 through sponging miR-4723-5p and recruiting USP14
|
[40]
|
|
High
|
Silencing PCAT6 inhibits the proliferation of triple-negative breast cancer cells and promoted apoptosis by upregulating the expression of miR-185-5p and downregulating the expression of TPD52
|
[38]
|
|
Bile duct cancer
|
High
|
Inhibits cell proliferation and invasion by reducing miR-330-5p expression in bile duct cancer cells
|
[42]
|
|
Pituitary adenoma
|
High
|
Promotes pituitary adenoma progression by targeting the miR-139-3p/ BRD4 axis
|
[45]
|
