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Fig. 3 | Cancer Cell International

Fig. 3

From: β-Catenin/LEF-1 transcription complex is responsible for the transcriptional activation of LINC01278

Fig. 3

Overexpression of β-catenin enhances the transcription of LINC01278 activated by LEF-1. A The immunoprecipitated promoter fragment containing the LEF-1 response element was probed by PCR using primers targeting the regulatory region of LINC01278 gene in TPC-1 and BCPAP cells which overexpressed β-catenin. The expression of β-catenin protein (B) and LINC01278 (C) in TPC-1 and BCPAP cells which were transfected with β-catenin siRNA (siRNA) or overexpression plasmid (β-catenin). D The LINC01278 levels in TPC-1 and BCPAP cells which were treated with Wnt/β-catenin specific agonists (LiCI) and inhibitors (WiKI4). *P < 0.05

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