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Fig. 4 | Cancer Cell International

Fig. 4

From: MiR-613 inhibits the proliferation, migration, and invasion of papillary thyroid carcinoma cells by directly targeting TAGLN2

Fig. 4

TAGLN2 as a direct target of miR-613. a Venn diagram displaying miR-613 predicated to target TAGLN2 based on four different predication algorithms, namely, TargetScan, miRDAB, RNAInter, and miRWalk. b Schematic representation of TAGLN2 showing the putative miRNA target site. c Suppression of the luciferase activity of TAGLN2-3`UTR by miR-613 in 293 T cells and removal of the miR-613-mediated inhibitory effect by TAGLN2-3`UTR-mut. d Decrease in TAGLN2 mRNA levels owing to the overexpression of miR-613 based on qRT-PCR analysis. e Decrease in TAGLN2 protein level owing to the overexpression of miR-613 based on western blot analysis. f Upregulation of TAGLN2 in papillary thyroid cancer (PTC) tissues compared with adjacent non-tumor tissues based on qRT-PCR and western blot analyses. The expression of miR-613 was inversely correlated with the expression of TAGLN2 mRNA. * p < 0.05, **p < 0.01, *** p < 0.001, **** p < 0.0001

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Cancer Cell International

ISSN: 1475-2867

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