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Table 1 List of GO enrichment analysis performed on GSE42352 (gene enrichment number Top10) and target (gene enrichment number Top10) database co-expressed differential genes by clusterProfiler package

From: PODN is a prognostic biomarker and correlated with immune infiltrates in osteosarcoma

Dataset

Ontology

ID

Description

P.adjust

Count

GSE42352

BP

GO:0030198

Extracellular matrix organization

4.25E−15

22

GSE42352

BP

GO:0043062

Extracellular structure organization

4.25E−15

22

GSE42352

BP

GO:0019882

Antigen processing and presentation

1.98E−10

15

GSE42352

BP

GO:0002478

Antigen processing and presentation of exogenous peptide antigen

8.65E−10

13

GSE42352

BP

GO:0019884

Antigen processing and presentation of exogenous antigen

1.25E−09

13

GSE42352

BP

GO:0048002

Antigen processing and presentation of peptide antigen

1.79E−09

13

GSE42352

BP

GO:0034341

Response to interferon-gamma

3.09E−09

13

GSE42352

BP

GO:0071346

Cellular response to interferon-gamma

1.19E−08

12

GSE42352

BP

GO:0002697

Regulation of immune effector process

0.000287702

12

GSE42352

BP

GO:0043312

Neutrophil degranulation

0.00042594

12

GSE42352

CC

GO:0062023

Collagen-containing extracellular matrix

1.39E−19

26

GSE42352

CC

GO:0010008

Endosome membrane

9.35E−07

14

GSE42352

CC

GO:0030139

Endocytic vesicle

4.96E−08

13

GSE42352

CC

GO:0005765

Lysosomal membrane

2.61E−07

13

GSE42352

CC

GO:0098852

Lytic vacuole membrane

2.61E−07

13

GSE42352

CC

GO:0005774

Vacuolar membrane

1.09E−06

13

GSE42352

CC

GO:0042611

MHC protein complex

1.00E−17

11

GSE42352

CC

GO:0005581

Collagen trimer

1.39E−11

11

GSE42352

CC

GO:0030666

Endocytic vesicle membrane

1.26E−08

11

GSE42352

CC

GO:0030133

Transport vesicle

2.34E−05

11

GSE42352

MF

GO:0005201

Extracellular matrix structural constituent

3.04E−17

18

GSE42352

MF

GO:0033218

Amide binding

1.06E−08

15

GSE42352

MF

GO:0042277

Peptide binding

1.06E−08

14

GSE42352

MF

GO:0005518

Collagen binding

1.21E−10

10

GSE42352

MF

GO:0004175

Endopeptidase activity

0.010282087

8

GSE42352

MF

GO:0042605

Peptide antigen binding

1.02E−08

7

GSE42352

MF

GO:0019838

Growth factor binding

8.98E−05

7

GSE42352

MF

GO:0003823

Antigen binding

0.000230162

7

GSE42352

MF

GO:0005539

Glycosaminoglycan binding

0.001734373

7

GSE42352

MF

GO:1901681

Sulfur compound binding

0.002670804

7

Target-OS

BP

GO:0030198

Extracellular matrix organization

6.15E−12

41

Target-OS

BP

GO:0043062

Extracellular structure organization

6.15E−12

41

Target-OS

BP

GO:0031589

Cell-substrate adhesion

2.67E−07

33

Target-OS

BP

GO:0001655

Urogenital system development

0.000137365

27

Target-OS

BP

GO:0034329

Cell junction assembly

0.010818905

25

Target-OS

BP

GO:0072001

Renal system development

0.00046375

24

Target-OS

BP

GO:0001503

Ossification

0.014822976

24

Target-OS

BP

GO:0001822

Kidney development

0.00057211

23

Target-OS

BP

GO:0007178

Transmembrane receptor protein serine/threonine kinase signaling pathway

0.00844363

23

Target-OS

BP

GO:0030111

Regulation of Wnt signaling pathway

0.016578746

22

Target-OS

CC

GO:0062023

Collagen-containing extracellular matrix

1.28E−09

38

Target-OS

CC

GO:0005925

Focal adhesion

2.57E−09

37

Target-OS

CC

GO:0030055

Cell-substrate junction

2.83E−09

37

Target-OS

CC

GO:0031252

Cell leading edge

9.36E−05

28

TargetOS

CC

GO:0005743

Mitochondrial inner membrane

0.001986238

27

Target-OS

CC

GO:0005759

Mitochondrial matrix

0.043195064

22

Target-OS

CC

GO:0031253

Cell projection membrane

0.002293285

21

Target-OS

CC

GO:0045121

Membrane raft

0.003431572

20

Target-OS

CC

GO:0098857

Membrane microdomain

0.003431572

20

Target-OS

CC

GO:0098589

Membrane region

0.005357409

20

Target-OS

MF

GO:0050839

Cell adhesion molecule binding

1.46E−08

43

Target-OS

MF

GO:0005201

Extracellular matrix structural constituent

3.19E−08

23

Target-OS

MF

GO:0005178

Integrin binding

2.43E−05

17

Target-OS

MF

GO:0019838

Growth factor binding

0.00016495

16

Target-OS

MF

GO:0030020

Extracellular matrix structural constituent conferring tensile strength

0.00016495

9

Target-OS

MF

GO:0003779

Actin binding

0.000286309

30

Target-OS

MF

GO:0048407

Platelet-derived growth factor binding

0.000577035

5

Target-OS

MF

GO:0045296

Cadherin binding

0.001118768

24

Target-OS

MF

GO:0051015

Actin filament binding

0.002243868

17

Target-OS

MF

GO:0008237

Metallopeptidase activity

0.029742453

14