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Fig. 3 | Cancer Cell International

Fig. 3

From: CircFBXL5 promotes the 5-FU resistance of breast cancer via modulating miR-216b/HMGA2 axis

Fig. 3

The relationship of circFBXL5 and miR-216b. A The binding sequence of circFBXL5 and miR-216b. B, C Luciferase activity was detected in cells with co-transfection of circFBXL5-WT or circFBXL5-MUT and miR-216b mimic or miR-con. D circFBXL5 expression in cells with transfection of biotin-miR-con or biotin-miR-216b after RNA pull-down. E miR-216b abundance in breast cancer tissues and normal tissues (nā€‰=ā€‰39). F circFBXL5 and miR-216b expression association in breast cancer tissues. G miR-216 abundance in breast cancer cell lines (MDA-MB-453 and MDA-MB-231) and normal human breast epithelial cell line MCF-10A. H miR-216 abundance in 5-FU-resistant and sensitive MDA-MB-231 and MDA-MB-453 cells. I, J miR-216 expression in cells with transfection of vector, circFBXL5 overexpression vector, si-circFBXL5 or si-con. Mock: non-transfected group. *Pā€‰<ā€‰0.05

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