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Fig. 1 | Cancer Cell International

Fig. 1

From: Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

Fig. 1

Regulatory role of genistein in cellular pathways. Genistein modulates receptor tyrosine kinase (RTKs) signal transduction. It prevents the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) explicitly either by the Akt pathway, Notch pathway, or by P53. It modulates the cell cycle by inhibiting cell cycle kinases and up-regulating Cyclin-Dependent Kinase inhibitors (CDKIs). It regulates ataxia telangiectasia mutated/F-box protein (ATM/AFR) through p53. Genistein also modulates metabolic pathways such as gluconeogenesis via the mTOR pathway. It up-regulates the Wnt pathway inhibitors and suppresses signal transduction by the Wnt pathway by inhibiting frizzled receptor and low density lipoprotein receptor-related protein (LPR) interactions and reduces β-catenin (B-cat) cytoplasmic accumulation. Genistein in the figure is depicted by “G’

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