Fig. 1From: Genistein as a regulator of signaling pathways and microRNAs in different types of cancersRegulatory role of genistein in cellular pathways. Genistein modulates receptor tyrosine kinase (RTKs) signal transduction. It prevents the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) explicitly either by the Akt pathway, Notch pathway, or by P53. It modulates the cell cycle by inhibiting cell cycle kinases and up-regulating Cyclin-Dependent Kinase inhibitors (CDKIs). It regulates ataxia telangiectasia mutated/F-box protein (ATM/AFR) through p53. Genistein also modulates metabolic pathways such as gluconeogenesis via the mTOR pathway. It up-regulates the Wnt pathway inhibitors and suppresses signal transduction by the Wnt pathway by inhibiting frizzled receptor and low density lipoprotein receptor-related protein (LPR) interactions and reduces β-catenin (B-cat) cytoplasmic accumulation. Genistein in the figure is depicted by “G’Back to article page