HOXB7 depletion impaired tumor growth in a HNSCC xenograft model.
A, B: Tumour volume was monitored in xenograft samples derived from Fad cells with stable HOXB7 knockdown or controls;
C: Final weight of tumour masses harvested from derived from Fadu cells with stable HOXB7 knockdown or controls was compared.
D: The marker indicative of HOXB7 knockdown and proliferative marker Ki67 and CSCs markers CD44 and CD133 were determined by immunohistochemical staining in xenograft samples derived from Fadu cells with stable HOXB7 knockdown or controls. Scale bar: 100 μm. Representative images are shown. *P < 0.05, **P < 0.01, Student’s t-test