Fig. 5
From: MINDY1 promotes bladder cancer progression by stabilizing YAP
MINDY1 depletion inhibits bladder cancer cell proliferation. A MINDY1 depletion inhibited cell proliferation in bladder cancer cells. B MINDY1 depletion induced G1 cell cycle arrest in bladder cancer cells. C MINDY1 depletion decreased clone formation capability of bladder cancer cells. D, E Representative images of EdU assay of bladder cancer cells. F MINDY1 depletion inhibits the tumor growth in vivo. T24 cells were stably transfected with lentivirus carrying a scrambled shRNA or MINDY1 shRNA. 1 × 106 T24 cells were injected to the right dorsal flank of each mouse (n = 6). Tumor sizes were measured every 5 days until the end of the experiment. G Representative images of immunohistochemical staining for Ki67, MINDY1 and YAP. *, P value < 0.05; **, P value < 0.01; ***, P value < 0.001