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Fig. 3 | Cancer Cell International

Fig. 3

From: Long noncoding RNA FER1L4 promotes the malignant processes of papillary thyroid cancer by targeting the miR-612/ Cadherin 4 axis

Fig. 3

Effects of FER1L4 on cell apoptosis, cell cycle, cell migration, and invasion. A, B Flow cytometric analysis in apoptotic rate and cell cycle arrest of K-1 and TPC-1 cells transfected with siRNA targeting FER1L4. C Expression level of apoptotic markers and cell cycle S phase checkpoint proteins in PTC cells after depletion of FER1L4. D–F Tumor growth in mice subcutaneously implanted with FER1L4 silenced TPC-1 cells, and the tumor images, growth curves and weight were shown (n = 5). G Representative images of immunohistochemistry staining of Ki67 in implanted tumor sections. Scale bars = 100 μm. H Effects of silencing FER1L4 on cellular migration by wound healing assay. I, J Transwell assays were conducted to investigate the influence of silencing FER1L4 or overexpression of FER1L4 on cellular migration and invasion. Scale bars = 100 μm. Error bars, mean ± SD. * P < 0.05; ** P < 0.01; *** P < 0.001

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