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Fig. 7 | Cancer Cell International

Fig. 7

From: Long noncoding RNA FER1L4 promotes the malignant processes of papillary thyroid cancer by targeting the miR-612/ Cadherin 4 axis

Fig. 7

CDH4 promoted PTC cell proliferation and invasion. A Implanted tumors in mice were harvested and photographed. B The final tumor weight of implanted tumors was calculated. C Immunohistochemistry analysis of CDH4 in PTC tissues and adjacent normal tissues. D, E Knockdown of CDH4 inhibited PTC cell migration and invasion as suggested by wound healing assays and transwell assays. Scale bars = 100 μm. F Detection of CDH4 protein level in TPC-1 cells co-transfected with miR-612 inhibitor and CDH4 siRNA. (G) Cellular growth curves of PTC cells co-transfected with miR-612 inhibitor and CDH4 siRNA determined by CCK8 assays. H, I Rescue effects of miR-612 inhibitor on CDH4 siRNA-mediated inhibition of cellular migration and invasion. Error bars, mean ± SD. * P < 0.05; ** P < 0.01; *** P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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