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Table 4 The kinase target networks of CXC chemokines in CC (LinkedOmics)

From: Analysis of therapeutic targets and prognostic biomarkers of CXC chemokines in cervical cancer microenvironment

CXC chemokines Enriched kinase target Description Leading EdgeNum p-value
CXCL1 Kinase_ATR ATR serine/threonine kinase 16 0
  Kinase_CHUK Conserved helix–loop–helix ubiquitous kinase 10 0
CXCL2 Kinase_RPS6KB1 Ribosomal protein S6 kinase B1 6 0
  Kinase_ATM ATM serine/threonine kinase 38 0
CXCL3 Kinase_GRK6 G-protein-coupled receptor kinase 6 2 0
  Kinase_ATM ATM serine/threonine kinase 37 0
CXCL5 Kinase_PAK2 p21 (RAC1) activated kinase 2 7 0
  Kinase_PAK3 p21 (RAC1) activated kinase 3 3 0
CXCL6 Kinase_DAPK1 Death-associated protein kinase 1 6 0
  Kinase_EGFR Epidermal growth factor receptor 20 0
CXCL9 Kinase_ZAP70 Zeta chain of T-cell receptor associated protein kinase 70 4 0
  Kinase_LCK LCK proto-oncogene, Src family tyrosine kinase 23 0
CXCL10 Kinase_LYN LYN proto-oncogene, Src family tyrosine kinase 21 0
  Kinase_LCK LCK proto-oncogene, Src family tyrosine kinase 21 0
CXCL11 Kinase_LCK LCK proto-oncogene, Src family tyrosine kinase 22 0
  Kinase_LYN LYN proto-oncogene, Src family tyrosine kinase 21 0
CXCL12 Kinase_RPS6KA4 Ribosomal protein S6 kinase A4 11 0
  Kinase_PLK3 Polo-like kinase 3 6 0
CXCL13 Kinase_LCK LCK proto-oncogene, Src family tyrosine kinase 22 0
  Kinase_SYK Spleen-associated tyrosine kinase 15 0
CXCL14 Kinase_CDK1 Cyclin-dependent kinase 1 74 0
  Kinase_MAP3K8 Mitogen-activated protein kinase kinase kinase 8 7 0
CXCL16 Kinase_LCK LCK proto-oncogene, Src family tyrosine kinase 23 0
  Kinase_LYN LYN proto-oncogene, Src family tyrosine kinase 22 0
CXCL17 Kinase_ADRBK1 G-protein-coupled receptor kinase 2 8 0
  Kinase_IGF1R Insulin-like growth factor 1 receptor 7 0