Table 4 The kinase target networks of CXC chemokines in CC (LinkedOmics)
CXC chemokines | Enriched kinase target | Description | Leading EdgeNum | p-value |
|---|---|---|---|---|
CXCL1 | Kinase_ATR | ATR serine/threonine kinase | 16 | 0 |
|  | Kinase_CHUK | Conserved helix–loop–helix ubiquitous kinase | 10 | 0 |
CXCL2 | Kinase_RPS6KB1 | Ribosomal protein S6 kinase B1 | 6 | 0 |
| Â | Kinase_ATM | ATM serine/threonine kinase | 38 | 0 |
CXCL3 | Kinase_GRK6 | G-protein-coupled receptor kinase 6 | 2 | 0 |
| Â | Kinase_ATM | ATM serine/threonine kinase | 37 | 0 |
CXCL5 | Kinase_PAK2 | p21 (RAC1) activated kinase 2 | 7 | 0 |
| Â | Kinase_PAK3 | p21 (RAC1) activated kinase 3 | 3 | 0 |
CXCL6 | Kinase_DAPK1 | Death-associated protein kinase 1 | 6 | 0 |
| Â | Kinase_EGFR | Epidermal growth factor receptor | 20 | 0 |
CXCL9 | Kinase_ZAP70 | Zeta chain of T-cell receptor associated protein kinase 70 | 4 | 0 |
| Â | Kinase_LCK | LCK proto-oncogene, Src family tyrosine kinase | 23 | 0 |
CXCL10 | Kinase_LYN | LYN proto-oncogene, Src family tyrosine kinase | 21 | 0 |
| Â | Kinase_LCK | LCK proto-oncogene, Src family tyrosine kinase | 21 | 0 |
CXCL11 | Kinase_LCK | LCK proto-oncogene, Src family tyrosine kinase | 22 | 0 |
| Â | Kinase_LYN | LYN proto-oncogene, Src family tyrosine kinase | 21 | 0 |
CXCL12 | Kinase_RPS6KA4 | Ribosomal protein S6 kinase A4 | 11 | 0 |
| Â | Kinase_PLK3 | Polo-like kinase 3 | 6 | 0 |
CXCL13 | Kinase_LCK | LCK proto-oncogene, Src family tyrosine kinase | 22 | 0 |
| Â | Kinase_SYK | Spleen-associated tyrosine kinase | 15 | 0 |
CXCL14 | Kinase_CDK1 | Cyclin-dependent kinase 1 | 74 | 0 |
| Â | Kinase_MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | 7 | 0 |
CXCL16 | Kinase_LCK | LCK proto-oncogene, Src family tyrosine kinase | 23 | 0 |
| Â | Kinase_LYN | LYN proto-oncogene, Src family tyrosine kinase | 22 | 0 |
CXCL17 | Kinase_ADRBK1 | G-protein-coupled receptor kinase 2 | 8 | 0 |
| Â | Kinase_IGF1R | Insulin-like growth factor 1 receptor | 7 | 0 |