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Fig. 1 | Cancer Cell International

Fig. 1

From: LncRNA HOTAIR promotes proliferation and inhibits apoptosis by sponging miR-214-3p in HPV16 positive cervical cancer cells

Fig. 1

HPV16 E7 promotes HOTAIR expression in cervical cancer cells by qPCR analysis. A HOTAIR was highly expressed in End1/E6E7 and SiHa cells, but HOTAIR level was very low in C-33A cells (HPV negative). B HPV16 E7 was highly expressed in End1/E6E7 and SiHa cells compared with C-33A cell. C Knockdown HPV16 E7 significantly inhibited the expression of HOTAIR in End1/E6E7 and SiHa cells, but there was no alteration in C-33A cell. D Upregulated expression of HPV16 E7 significantly promoted HOTAIR expression in all cervical cancer cells. The mean values and standard error were obtained from three independent experiments. GAPDH was used as an endogenous control gene. *P < 0.05, **P < 0.01, ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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