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Table 2 GO and pathway enrichment analysis of target genes of miR-214-3p

From: LncRNA HOTAIR promotes proliferation and inhibits apoptosis by sponging miR-214-3p in HPV16 positive cervical cancer cells

Term ID Term description Gene count Strength FDR
Biological processes
GO:0009987 Cellular process 1186 0.03 1.1E−04
GO:0065007 Biological regulation 979 0.04 1.1E−04
GO:0050789 Regulation of biological process 942 0.05 2.92E−05
GO:0050794 Regulation of cellular process 896 0.05 2.88E−05
GO:0008152 Metabolic process 818 0.05 1.1E−04
Cell component
GO:0005623 Cell 1312 0.03 1.39E−07
GO:0005622 Intracellular 1225 0.06 7.97E−16
GO:0043226 Organelle 1062 0.05 5.67E−09
GO:0043229 Intracellular organelle 1042 0.05 1.28E−08
GO:0005737 Cytoplasm 993 0.07 1.68E−11
Molecular function
GO:0005488 Binding 1006 0.05 3.75E−06
GO:0005515 Protein binding 614 0.09 1.33E−06
GO:0043167 Ion binding 541 0.07 1.1E−03
GO:0003824 Catalytic activity 499 0.07 2.6E−03
GO:0097159 Organic cyclic compound binding 464 0.06 3.41E−02
KEGG pathways
hsa04310 Wnt signaling pathway 32 0.47 1.1E−04
hsa04390 Hippo signaling pathway 30 0.42 7.5E−04
hsa04550 Signaling pathways regulating pluripotency of stem cells 28 0.43 7.5E−04
hsa04261 Adrenergic signaling in cardiomyocytes 27 0.41 3.7E−03
hsa05200 Pathways in cancer 67 0.24 3.7E−03
Reactome pathways
HSA-3238698 WNT ligand biogenesis and trafficking 11 0.75 2.23E−02
HSA-198725 Nuclear events (kinase and transcription factor activation) 9 0.68 4.12E−02
HSA-450282 MAPK targets/ nuclear events mediated by MAP kinases 10 0.63 4.12E−02
HSA-8986944 Transcriptional regulation by MECP2 16 0.56 2.23E−02
HSA-187037 Signaling by NTRK1 (TRKA) 18 0.5 2.23E−02
  1. GO gene ontology, KEGG Kyoto Encyclopedia of Genes and Genomes, FDR false discovery rate