Table 2 GO and pathway enrichment analysis of target genes of miR-214-3p
Term ID | Term description | Gene count | Strength | FDR |
|---|---|---|---|---|
Biological processes | ||||
GO:0009987 | Cellular process | 1186 | 0.03 | 1.1E−04 |
GO:0065007 | Biological regulation | 979 | 0.04 | 1.1E−04 |
GO:0050789 | Regulation of biological process | 942 | 0.05 | 2.92E−05 |
GO:0050794 | Regulation of cellular process | 896 | 0.05 | 2.88E−05 |
GO:0008152 | Metabolic process | 818 | 0.05 | 1.1E−04 |
Cell component | ||||
GO:0005623 | Cell | 1312 | 0.03 | 1.39E−07 |
GO:0005622 | Intracellular | 1225 | 0.06 | 7.97E−16 |
GO:0043226 | Organelle | 1062 | 0.05 | 5.67E−09 |
GO:0043229 | Intracellular organelle | 1042 | 0.05 | 1.28E−08 |
GO:0005737 | Cytoplasm | 993 | 0.07 | 1.68E−11 |
Molecular function | ||||
GO:0005488 | Binding | 1006 | 0.05 | 3.75E−06 |
GO:0005515 | Protein binding | 614 | 0.09 | 1.33E−06 |
GO:0043167 | Ion binding | 541 | 0.07 | 1.1E−03 |
GO:0003824 | Catalytic activity | 499 | 0.07 | 2.6E−03 |
GO:0097159 | Organic cyclic compound binding | 464 | 0.06 | 3.41E−02 |
KEGG pathways | ||||
hsa04310 | Wnt signaling pathway | 32 | 0.47 | 1.1E−04 |
hsa04390 | Hippo signaling pathway | 30 | 0.42 | 7.5E−04 |
hsa04550 | Signaling pathways regulating pluripotency of stem cells | 28 | 0.43 | 7.5E−04 |
hsa04261 | Adrenergic signaling in cardiomyocytes | 27 | 0.41 | 3.7E−03 |
hsa05200 | Pathways in cancer | 67 | 0.24 | 3.7E−03 |
Reactome pathways | ||||
HSA-3238698 | WNT ligand biogenesis and trafficking | 11 | 0.75 | 2.23E−02 |
HSA-198725 | Nuclear events (kinase and transcription factor activation) | 9 | 0.68 | 4.12E−02 |
HSA-450282 | MAPK targets/ nuclear events mediated by MAP kinases | 10 | 0.63 | 4.12E−02 |
HSA-8986944 | Transcriptional regulation by MECP2 | 16 | 0.56 | 2.23E−02 |
HSA-187037 | Signaling by NTRK1 (TRKA) | 18 | 0.5 | 2.23E−02 |