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Fig. 4 | Cancer Cell International

Fig. 4

From: Identification and integrative analysis of ACLY and related gene panels associated with immune microenvironment reveal prognostic significance in hepatocellular carcinoma

Fig. 4

ACLY acted as an upstream regulator had close association with fatty acid and cholesterol biosynthesis and correlated with immune checkpoints in HCC. A Expression of fatty acid biosynthesis pathway related genes. B Expression of cholesterol biosynthesis pathway related genes. C Proteomic interactions between ACLY and core participants in fatty acid biosynthesis. D Proteomic interactions between ACLY and core participants in cholesterol biosynthesis. E Communication between lipid metabolism and immune checkpoints induced by ACLY and AKT1. F, G Correlation of ACLY and CD276 transcriptomic level and differentiated expression of CD276 in high ACLY expression and low ACLY expression group in both GSE77509 and TCGA cohort. HK Other clinically approved and potential immune checkpoints correlated with ACLY in TCGA cohort

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