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Fig. 7 | Cancer Cell International

Fig. 7

From: WD40 repeat 43 mediates cell survival, proliferation, migration and invasion via vimentin in colorectal cancer

Fig. 7

WDR43 knockdown suppresses VIM expression. The levels of several proteins associated with tumor cell proliferation and migration as well as their phosphorylated forms were examined by western blotting in DLD-1 cells, as were those of classical signaling pathway proteins. CDH1 E-cadherin, CDH2 N-cadherin, FN1 fibronectin 1, (p-)AKT (phosphorylated-)protein kinase B, MMP-2 matrix metalloproteinase-2, (p-)mTOR (phosphorylated-)mechanistic target of rapamycin, (p-)NF-κB p65 (phosphorylated-)nuclear factor-κB p65, (p-)ERK1/2 (phosphorylated-)extracellular signal-regulated kinase1/2; VIM vimentin, NC negative control, KD WDR43 knockdown

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