Fig. 7From: WD40 repeat 43 mediates cell survival, proliferation, migration and invasion via vimentin in colorectal cancerWDR43 knockdown suppresses VIM expression. The levels of several proteins associated with tumor cell proliferation and migration as well as their phosphorylated forms were examined by western blotting in DLD-1 cells, as were those of classical signaling pathway proteins. CDH1 E-cadherin, CDH2 N-cadherin, FN1 fibronectin 1, (p-)AKT (phosphorylated-)protein kinase B, MMP-2 matrix metalloproteinase-2, (p-)mTOR (phosphorylated-)mechanistic target of rapamycin, (p-)NF-κB p65 (phosphorylated-)nuclear factor-κB p65, (p-)ERK1/2 (phosphorylated-)extracellular signal-regulated kinase1/2; VIM vimentin, NC negative control, KD WDR43 knockdownBack to article page