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Fig. 1 | Cancer Cell International

Fig. 1

From: Blocking circ-SCMH1 (hsa_circ_0011946) suppresses acquired DDP resistance of oral squamous cell carcinoma (OSCC) cells both in vitro and in vivo by sponging miR-338-3p and regulating LIN28B

Fig. 1

Expression of circRNA derived from SCMH1 (hsa_circ_0011946, circ-SCMH1) in cis-dichlorodiammineplatinum (DDP)-resistant oral squamous cell carcinoma (OSCC) tissues and cells. RT-qPCR detected circ-SCMH1 level with normalization to GAPDH in A DDP-resistant tumor tissues (Resistant; N = 31) and DDP-sensitive tumor tissues (Sensitive; N = 31), and B DDP-resistant OSCC cell lines (SCC-15/DDP and CAL-27/DDP) and the parental cell lines (SCC-15 and CAL-27), compared to normal human oral keratinocytes (HOK). In SCC-15/DDP and CAL-27/DDP cells, C–F RT-qPCR examined RNA levels of C, D circ-SCMH1 and linear SCMH1 after RNase R treatment or Mock treatment and E, F circ-SCMH1, U6 and GAPDH in the cytoplasm and nucleus with normalization to GAPDH. *P < 0.05, **P < 0.01, and ****P < 0.0001 from three separate assays

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