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Table 3 Correlation between AURKA intensity and clinical features based on GSE136755

From: Aurora kinase A (AURKA) promotes the progression and imatinib resistance of advanced gastrointestinal stromal tumors

Parameter

Characteristic

No. patients (%)

AURKA intensity

Statistics

P value

Gender

Female

26 (40.0)

6.19 ± 0.97

t = − 1.458

0.150

Male

39 (60.0)

6.63 ± 1.47

  

Age

< 68

31 (47.7)

6.28 ± 1.17

t = 1.022

0.311

≥ 68

34 (52.3)

6.62 ± 1.41

  

Location*

Stomach

43 (66.2)

6.14 ± 1.25

 F = 4.306

0.018

Non-stomach

16 (24.6)

6.95 ± 0.99

  

Metastasis

6 (9.2)

7.39 ± 1.74

  

Risk*

High

17 (26.2)

7.54 ± 1.30

 F = 11.898

< 0.001

Intermediate

9 (13.8)

5.75 ± 0.54

  

Low

22 (33.8)

6.06 ± 0.94

  

Very low

11 (16.9)

5.66 ± 0.74

  

Stage*

IV

9 (13.8)

7.94 ± 1.63

 F = 10.686

< 0.001

III

9 (13.8)

6.85 ± 0.89

  

II

8 (12.3)

7.13 ± 1.55

  

I

39 (60.0)

5.89 ± 0.84

  

Mutation

Sensitive

56 (86.2)

6.39 ± 1.21

 F = 2.541

0.087

Resistance

7 (10.8)

7.33 ± 1.84

  

 N/A

2 (3.1)

5.29 ± 0.20

  

Mutation

Sensitive

56 (88.9)

6.39 ± 1.21

t = 1.814

0.075

Resistance

7 (11.1)

7.33 ± 1.84

  
  1. *P < 0.05 was considered statistically significant