Skip to main content
Fig. 2 | Cancer Cell International

Fig. 2

From: Exosomal circRNAs: new players in colorectal cancer

Fig. 2

Biogenesis and function of circRNAs. CircRNAs are produced by back-splicing, wrap up into exosomes, and secreted into the extracellular environment. The potential functions of circRNAs in multiple biological processes have been identified, including miRNA sponges, alternative splicing, and transcriptional or post-transcriptional gene regulation. CircRNAs are mainly act as miRNA sponge to control expression of target genes via preventing the of miRNA activity. CircRNAs also adjust gene expression via attachment to miRNAs and releasing them from their target genes. Some circRNAs that exhibit attachment sites for RPB may function as protein sponges besides from performing as miRNA sponges

Back to article page