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Table 1 The prospective diagnostic and therapeutic biomarkers of exo-circRNAs related to CRC

From: Exosomal circRNAs: new players in colorectal cancer

circRNA Role/Function Regulation Sample References
circKLDHC10 Biomarker Serum exosome [19]
hsa_circ_0004771 Biomarker Cell line; seum exosome [38]
hsa_circ_0101802 Biomarker Serum exosome [39]
hsa_circ_0000338 Drug resistance Cell line; serum exosome [42]
circ_0032883 Drug resistance Cell line exosome [42]
circ_0066629 Drug resistance Cell line exosome [42]
ciRS-122 Drug resistance Cell line exosome [43]
circ-FBXW7 Drug resistance Cell line; serum exosome [44]
circ-PACRGL Enhanced proliferation and invasion of cancer cells via miR-142-3p/miR-506-3p sponge to support the expression of TGF-β1 Cell line exosome [45]
circ-133 Biomarker/enhanced metastasis via miR-133a/GEF-H1/RhoA axis Serum exosome [46]
hsa_circ_0008558 Enhanced metastasis via modifying the maturation and allocation of miR-17 Cell line exosome [47]
circ_IFT80 Enhanced proliferation and inhibited radiosensitivity by regulating miR-296-5p/MSI1 axis Cell line; serum exosome [48, 49]
hsa_circ_0000677 Biomarker/enhanced metastasis and stemness properties possibly by upregulation of circ_0000677 via Wnt pathway Cell line exosome [50]
circFAT1and circRTN4 Downregulation of circFAT1 and circRTN4 in mutant cells, suggesting a potential involvement of circRNAs in oncogenesis via increased exporting of the circRNAs to exosomes KRAS mutant cell line exosome [51]