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Table 1 The prospective diagnostic and therapeutic biomarkers of exo-circRNAs related to CRC

From: Exosomal circRNAs: new players in colorectal cancer

circRNA

Role/Function

Regulation

Sample

References

circKLDHC10

Biomarker

↑

Serum exosome

[19]

hsa_circ_0004771

Biomarker

↑

Cell line; seum exosome

[38]

hsa_circ_0101802

Biomarker

↑

Serum exosome

[39]

hsa_circ_0000338

Drug resistance

↑

Cell line; serum exosome

[42]

circ_0032883

Drug resistance

↑

Cell line exosome

[42]

circ_0066629

Drug resistance

↑

Cell line exosome

[42]

ciRS-122

Drug resistance

↑

Cell line exosome

[43]

circ-FBXW7

Drug resistance

↓

Cell line; serum exosome

[44]

circ-PACRGL

Enhanced proliferation and invasion of cancer cells via miR-142-3p/miR-506-3p sponge to support the expression of TGF-β1

↑

Cell line exosome

[45]

circ-133

Biomarker/enhanced metastasis via miR-133a/GEF-H1/RhoA axis

↑

Serum exosome

[46]

hsa_circ_0008558

Enhanced metastasis via modifying the maturation and allocation of miR-17

↑

Cell line exosome

[47]

circ_IFT80

Enhanced proliferation and inhibited radiosensitivity by regulating miR-296-5p/MSI1 axis

↑

Cell line; serum exosome

[48, 49]

hsa_circ_0000677

Biomarker/enhanced metastasis and stemness properties possibly by upregulation of circ_0000677 via Wnt pathway

↑

Cell line exosome

[50]

circFAT1and circRTN4

Downregulation of circFAT1 and circRTN4 in mutant cells, suggesting a potential involvement of circRNAs in oncogenesis via increased exporting of the circRNAs to exosomes

↑

KRAS mutant cell line exosome

[51]