Fig. 1

Significant lncRNA profile changes and downregulation of lnc-STYK1-2 expression in bladder cancer tissues. A A scatterplot showing the differential expression of lncRNAs between bladder cancer tissues and corresponding adjacent noncancerous bladder tissues. The expression of lncRNA between bladder cancer tissues and adjacent noncancerous bladder tissues was detected by high-throughput RNA sequencing. Upregulated, downregulated, and nonaltered lncRNAs are presented as red, green, and blue spots in the plot, respectively. B Hierarchical clustering of differentially expressed lncRNAs between bladder cancer tissues and the corresponding adjacent noncancerous bladder tissues. Relative higher and lower lncRNA expressions are indicated by red and blue colors, respectively. C Venn plots showing the numbers of significantly upregulated and downregulated lncRNAs between bladder cancer tissues and corresponding adjacent noncancerous bladder tissues. D Relative expression of lnc-STYK1-2 in cancerous and adjacent noncancerous bladder tissue samples collected from 16 patients. The lnc-STYK1-2 expression levels in bladder tissues were detected by quantitative RT-PCR. RPKM: reads per kilobase per million mapped reads; FDR: fold change ratio; DETs: differentially expressed transcripts; STYK1: serine/threonine/tyrosine kinase 1