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Fig. 2 | Cancer Cell International

Fig. 2

From: Lnc-STYK1-2 regulates bladder cancer cell proliferation, migration, and invasion by targeting miR-146b-5p expression and AKT/STAT3/NF-kB signaling

Fig. 2

Promotion of bladder cancer cell proliferation, migration, and invasion by lnc-STYK1-2 silencing. A Relative expression levels of lnc-STYK1-2 in different bladder cancer cell lines. The expression of lnc-STYK1-2 in bladder cancer cell lines UM-UC-3, TCCSUP, T24, and 5637 was measured by quantitative RT-PCR. B Silenced lnc-STYK1-2 expression in T24 and 5637 cells by transfection with siRNAs targeting lnc-STYK1-2. The expression of lnc-STYK1-2 in T24 and 5637 cells was assessed by quantitative RT-PCR. C The alterations in T24 and 5637 cell proliferation induced by lnc-STYK1-2 silencing. Bladder cancer cell proliferation was evaluated through the MTS assay. D, E Enhanced migration and invasion capacities of bladder cancer cell lines by lnc-STYK1-2 silencing. The migration (D) and invasion (E) capacities of T24 and 5637 cells were detected using the Transwell system following lnc-STYK1-2 silencing. STYK1: serine/threonine/tyrosine kinase 1; NC: negative control; si-lnc-STYK1-2: siRNAs targeting lnc-STYK1-2; *P < 0.05; **P < 0.01

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Cancer Cell International

ISSN: 1475-2867

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