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Fig. 3 | Cancer Cell International

Fig. 3

From: Lnc-STYK1-2 regulates bladder cancer cell proliferation, migration, and invasion by targeting miR-146b-5p expression and AKT/STAT3/NF-kB signaling

Fig. 3

Enhanced tumorigenesis of bladder cancer cells by lnc-STYK1-2 silencing. A, B Significant suppression of lnc-STYK1-2 expression in the T24 and 5637 cells by lentivirus-mediated infection with shRNAs targeting lnc-STYK1-2. The expression of lnc-STYK1-2 in T24 and 5637 cells was detected by quantitative RT-PCR following recombinant lentivirus infection. C Greatly decreased sizes of tumors formed in nude mice injected with T24 and 5637 cells with lnc-STYK1-2 silencing. The tumors formed in mice were surgically collected 30 days after the injection of bladder cancer cells. D Quantitative analysis of the fresh weights of tumors originating from T24 and 5637 cells, with lnc-STYK1-2 silencing in nude mice. Sh: shRNA; NC: negative control; STYK1: serine/threonine/tyrosine kinase 1; ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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