Fig. 5

OGFRP1 exerts its role through regulating miR-4640-5p/eIF5A axis. A The sequences of miR-4640-5p, wide type of eIF5A (WT) and mutated eIF5A (Mut). B The protein expression of eIF5A in 25 pairs of LUAD and normal lung tissues. Overall (C) and disease-free (D) survival curves of LUAD patients with different eIF5A expression. The result of C and D derived from GEPIA (http://gepia.cancer-pku.cn/), which was based on the database of TCGA and GTEx. E The correlation between miR-4640-5p with eIF5A levels in 25 pairs of clinically collected LUAD and normal lung tissue samples. F The correlation between OGFRP1 with eIF5A levels in 25 pairs of clinically collected LUAD and normal lung tissue samples. G The expression levels of luciferase of A549 cells transfected with wild-type (WT) or mutated (Mut) eIF5A reporters plus miR-4640-5p mimic or miR-NC were determined. H The protein expression of eIF5A. * represented P < 0.05