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Table 3 Distribution frequency of WISP1polymorphisms in controls and gastric cancer patients stratified by clinical stage

From: Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese

Variables Clinical stage I/II Clinical stage III/IV
Controls (N = 227) Cancer (N = 60) *OR (95% CI) P Cancer (N = 144) AOR (95% CI) P
rs2929973
 Co-dominant TT 102 (44.9) 26 (43.3) 1.00ref   74 (51.4) 1.00ref  
 TG 91 (40.1) 28 (46.7) 1.30 (0.46–3.70) 0.624 57 (39.6) 0.88 (0.54–1.42) 0.591
 GG 34 (15.0) 6 (10.0) 1.71 (0.60–4.85) 0.315 13 (9.0) 0.58 (0.28–1.21) 0.144
 Dominant TT 102 (44.9) 26 (43.3) 1.00ref   74 (51.4) 1.00ref  
 TG + GG 125 (55.1) 34 (56.7) 1.17 (0.62–2.20) 0.636 70 (48.6) 0.78 (0.50–1.23) 0.286
 Recessive TT + TG 193 (85.0) 54 (90.0) 1.00ref   131 (91.0) 1.00ref  
 GG 34 (15.0) 6 (10.0) 0.67 (0.25–1.81) 0.433 13 (9.0) 0.61 (0.30–1.23) 0.163
rs7843546
 Co-dominant CC 36 (15.9) 17 (28.3) 1.00ref   24 (16.7) 1.00ref  
 CT 119 (52.4) 30 (50.0) 0.54 (0.25–1.17) 0.116 79 (54.9) 1.08 (0.58–2.02) 0.808
 TT 72 (31.7) 13 (21.7) 0.34 (0.14–0.84) 0.020* 41 (28.5) 0.90 (0.46–1.77) 0.756
 Dominant CC 36 (15.9) 17 (28.3) 1.00ref   24 (16.7) 1.00ref  
 CT + TT 191 (84.1) 43 (71.7) 0.46 (0.22–0.96) 0.038* 120 (83.3) 1.02 (0.56–1.85) 0.953
 Recessive CT + CC 155 (68.3) 47 (78.3) 1.00ref   103 (71.5) 1.00ref  
 TT 72 (31.7) 13 (21.7) 0.52 (0.25–1.10) 0.087 41 (28.5) 0.87 (0.54–1.41) 0.569
rs10956697
 Co-dominant CC 86 (37.9) 26 (43.3) 1.00ref   69 (47.9) 1.00ref  
 AC 114 (50.2) 27 (45.0) 0.84 (0.43–1.63) 0.609 61 (42.4) 0.72 (0.45–1.16) 0.176
 AA 27 (11.9) 7 (11.7) 1.08 (0.38–3.03) 0.888 14 (9.7) 0.83 (0.39–1.79) 0.636
 Dominant CC 86 (37.9) 26 (43.3) 1.00ref   69 (47.9) 1.00ref  
 AC + AA 141 (62.1) 34 (56.7) 0.88 (0.47–1.66) 0.696 75 (52.1) 0.73 (0.46–1.14) 0.166
 Recessive CC + AC 200(88.1) 53 (88.3) 1.00ref   130 (90.3) 1.00ref  
 AA 27 (11.9) 7 (11.7) 1.18 (0.45–3.13) 0.739 14 (9.7) 0.97 (0.47–2.01) 0.943
  1. ref reference; AOR Adjusted odds ratio; 95% CI 95% confidence interval; adjusted for age, BMI ethnicity, smoking and drinking alcohol
  2. * P < 0.05 as statically significant