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Table 3 Distribution frequency of WISP1polymorphisms in controls and gastric cancer patients stratified by clinical stage

From: Association between WNT-1-inducible signaling pathway protein-1 (WISP1) genetic polymorphisms and the risk of gastric cancer in Guangxi Chinese

Variables

Clinical stage I/II

Clinical stage III/IV

Controls (N = 227)

Cancer (N = 60)

*OR (95% CI)

P

Cancer (N = 144)

AOR (95% CI)

P

rs2929973

 Co-dominant TT

102 (44.9)

26 (43.3)

1.00ref

 

74 (51.4)

1.00ref

 

 TG

91 (40.1)

28 (46.7)

1.30 (0.46–3.70)

0.624

57 (39.6)

0.88 (0.54–1.42)

0.591

 GG

34 (15.0)

6 (10.0)

1.71 (0.60–4.85)

0.315

13 (9.0)

0.58 (0.28–1.21)

0.144

 Dominant TT

102 (44.9)

26 (43.3)

1.00ref

 

74 (51.4)

1.00ref

 

 TG + GG

125 (55.1)

34 (56.7)

1.17 (0.62–2.20)

0.636

70 (48.6)

0.78 (0.50–1.23)

0.286

 Recessive TT + TG

193 (85.0)

54 (90.0)

1.00ref

 

131 (91.0)

1.00ref

 

 GG

34 (15.0)

6 (10.0)

0.67 (0.25–1.81)

0.433

13 (9.0)

0.61 (0.30–1.23)

0.163

rs7843546

 Co-dominant CC

36 (15.9)

17 (28.3)

1.00ref

 

24 (16.7)

1.00ref

 

 CT

119 (52.4)

30 (50.0)

0.54 (0.25–1.17)

0.116

79 (54.9)

1.08 (0.58–2.02)

0.808

 TT

72 (31.7)

13 (21.7)

0.34 (0.14–0.84)

0.020*

41 (28.5)

0.90 (0.46–1.77)

0.756

 Dominant CC

36 (15.9)

17 (28.3)

1.00ref

 

24 (16.7)

1.00ref

 

 CT + TT

191 (84.1)

43 (71.7)

0.46 (0.22–0.96)

0.038*

120 (83.3)

1.02 (0.56–1.85)

0.953

 Recessive CT + CC

155 (68.3)

47 (78.3)

1.00ref

 

103 (71.5)

1.00ref

 

 TT

72 (31.7)

13 (21.7)

0.52 (0.25–1.10)

0.087

41 (28.5)

0.87 (0.54–1.41)

0.569

rs10956697

 Co-dominant CC

86 (37.9)

26 (43.3)

1.00ref

 

69 (47.9)

1.00ref

 

 AC

114 (50.2)

27 (45.0)

0.84 (0.43–1.63)

0.609

61 (42.4)

0.72 (0.45–1.16)

0.176

 AA

27 (11.9)

7 (11.7)

1.08 (0.38–3.03)

0.888

14 (9.7)

0.83 (0.39–1.79)

0.636

 Dominant CC

86 (37.9)

26 (43.3)

1.00ref

 

69 (47.9)

1.00ref

 

 AC + AA

141 (62.1)

34 (56.7)

0.88 (0.47–1.66)

0.696

75 (52.1)

0.73 (0.46–1.14)

0.166

 Recessive CC + AC

200(88.1)

53 (88.3)

1.00ref

 

130 (90.3)

1.00ref

 

 AA

27 (11.9)

7 (11.7)

1.18 (0.45–3.13)

0.739

14 (9.7)

0.97 (0.47–2.01)

0.943

  1. ref reference; AOR Adjusted odds ratio; 95% CI 95% confidence interval; adjusted for age, BMI ethnicity, smoking and drinking alcohol
  2. * P < 0.05 as statically significant